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Melanocortin 1 Receptor-Signaling Deficiency Results in an Articular Cartilage Phenotype and Accelerates Pathogenesis of Surgically Induced Murine Osteoarthritis

Figure 5

Comparison of bone architecture between Mc1re/e and WT mice at the day of DMM surgery (day 0) using µCT.

A–F) µCT 3D analysis of bone parameters was performed within a defined VOI including the tibia epiphysis of both knees respectively. A) Frontal view on 3D model of the proximal tibia of the right leg showing the VOI marked in purple (L: lateral, M: medial). B) µCT analysis of mean grayscale within the VOI as an indicator for bone density indicated no difference between WT and Mc1re/e mice. C) 3D calculation of BV/TV within the VOI as an indicator of bone mass also revealed no difference between both groups. In Trabecular number (Tb.N, D) and trabecular thickness (Tb.Th, E) no difference was observed whereas trabecular separation (Tb.Sp, F) was increased in Mc1re/e compared to controls (p = 0.028). Values of left and right knees were combined. Data are presented as boxplots reflecting the 25th and 75th percentile as boxes, the median as horizontal line and minimum and maximum values as whiskers, stars indicating extreme outliers. * p<0.05 wild type vs. Mc1re/e.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0105858.g005