The Effect of Lentivirus-Mediated PSPN Genetic Engineering Bone Marrow Mesenchymal Stem Cells on Parkinson’s Disease Rat Model
Figure 6
The change of EGFP-labeled rMSCs after stereotactic injection into the striatum of PD rats.
(A) Cells were injected into the striatum through needle passage with microsyringe. (B–E) The fluorescence intensity in Lv-PSPN-MSCs group is stronger than Lv-null-MSCs group no matter in the first week or second week. Over a period of 4 weeks following grafting, EGFP-labeled rMSCs could be detected at various locations. rMSCs could be detected within the striatum (F) while others had already attached either to the contralateral striatum (G), periventricular regions (H–I) and cerebral cortex (J). Single cells even exhibit processes resembling neuronal morphologies (K). Scale bar = 200 µm.