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In Silico Determination of the Effect of Multi-Target Drugs on Calcium Dynamics Signaling Network Underlying Sea Urchin Spermatozoa Motility

Figure 2

Niflumic acid increases the []i mean, maximum peak, amplitude and interval between successive [Ca2+] fluctuations.

Experimental determination of the -sensitive colorant Fluo-4 fluorescence in the flagellum, averaged along its length, of sperm exposed to 100 nM caged speract, in the absence of NFA (black trace) and the presence of 10 M of NFA (red trace). Concentration is measured in florescence intensity (F.I) units and time in seconds according to the scale shown in the inset on the upper right part of the figure. The figure is a modified version of the equivalent shown in [4].

Figure 2

doi: https://doi.org/10.1371/journal.pone.0104451.g002