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The p38α MAPK Function in Osteoprecursors Is Required for Bone Formation and Bone Homeostasis in Adult Mice

Figure 4

μCT evidences osteopenic bones in p38α deficient bones of 12-week-old mice.

(A) The distal epiphysis of femurs from control and knockout littermates were analysed by μCT. Trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp.) were determined (n = 8 (KO) and 12(FF)). (B) Femur cortical bone analysis of 12-week-old male mice revealed that knockout mice had decreased cortical volume and thickness around the midshaft. Bone volume (BV), bone area (B.Ar), bone perimeter (B.Pm) and cortical thickness (Ct.Th) were determined (n = 6 (KO) and 12 (FF)) (*p<0.05; **p<0.01; ***p<0.001). Differences between values from KO and FF mice (expressed as %) are also included (C) Representative images of distal femur diaphysis and (D) femur cortical bone from control and knockout mice are also shown.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0102032.g004