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Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity

Figure 7

STAT3 activation is preceded by enhanced expression of proinflammatory ligands in multiple models of neurotoxicity.

Mice were administered MPTP, AMP, METH, MDA, MDMA, KA and TMT with saline (0.9%) as a control and were killed at 6, 12 and 72 hours post dosing. Total RNA was prepared from striatum (MPTP, AMP, METH, MDA and MDMA) or hippocampus (KA and TMT) for qRT-PCR analysis of Tnf-α, Osm, Ccl2 or Lif. All data points represent mean ± SEM, N = 5. Statistical significance was measured by one-way ANOVA with Fisher's LSD Method of post hoc analysis. Statistical significance of at least p<0.05 for the neurotoxicant exposed groups in comparison to saline controls is denoted by an asterisk. See Methods for dosing regimen (multi-dose METH).

Figure 7

doi: https://doi.org/10.1371/journal.pone.0102003.g007