Functional Motor Recovery from Motoneuron Axotomy Is Compromised in Mice with Defective Corticospinal Projections
Figure 7
Regeneration estimated by GAP-43 expression in the post surgery spinal cord.
In transverse sections at C6, GAP-43 immunoreactivity (ir) is concentrated in the ventral horn (VH) on the lesion side on days 7, 14 and 21 post surgery, reaching maximal level on day 14, in both the control (A–C) and the mutant (D–F). At each time-point, GAP-43 expression is higher in the control than the mutant (G). *, P<0.05; **, P<0.01; comparison at different time-points with t-test, n = 4 mice in each group.