FOXO3a Potentiates hTERT Gene Expression by Activating c-MYC and Extends the Replicative Life-Span of Human Fibroblast
Figure 5
Schematic representation of FOXO3a-induced activation of hTERT transcription.
FOXO3a, a downstream target molecule of SIRT1, binds to the downstream FOXO binding element (DBE) in the c-MYC promoter and activates the transcription of c-MYC, which results in the increased transcription of hTERT gene in an E-box dependent manner.