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DTI Analysis in Patients with Primary Open-Angle Glaucoma: Impact of Registration on Voxel-Wise Statistics

Figure 3

Voxel-wise statistics, axial ROI.

(A) Axial ROI. (B) Standard deviation map of all aligned FA maps for each registration approach. (C) Mean FA skeleton for each registration approach: green (T, standard template), blue (GM, group mean), light blue (GW, group-wise atlas) and black (N, most representative subject) overlaid onto the mean FA image of the respective registration approach. Clusters of voxels of significantly decreased FA values of POAG patients compared to controls are marked red (p<0.05, corrected for multiple comparisons). *Coordinate in MNI_152 space.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0099344.g003