Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity
Figure 4
Dose-dependent antinociceptive effects produced by morphine, oxymorphone and N-methylmorphinans 1, 4 and 6.
(A) Hot-plate test. (B) Tail-flick test. Hot-plate and tail-flick latencies (as %MPE) are shown at 30 min (peak of action) after s.c. drug administration to mice. Data are shown as the mean ± SEM (n = 5–6 mice per group).