Individual Differences in Ethanol Locomotor Sensitization Are Associated with Dopamine D1 Receptor Intra-Cellular Signaling of DARPP-32 in the Nucleus Accumbens
Figure 2
There is clear individual variability to the development of sensitization to ethanol.
Locomotor activity for 15(means ± S.E.M.) of mice treated with saline or 2.2 g/kg ethanol i.p. (classified as non-sensitized (nsens) or sensitized (sens) based on their locomotor activity in the 21st day test) in the tests performed on days 1, 7, 14 and 21. (A) Cohort of mice (saline, n = 8; nsens, n = 5; sens, n = 8) that received the lower dose of SKF during the challenge phase. (B) Cohort of mice (saline, n = 11; nsens, n = 6; sens, n = 7) that received the higher dose of SKF during the challenge phase. (C) Cohort of mice (saline, n = 8; nsens, n = 8; sens, n = 9) that was designed for DARPP-32 measures after saline administration. (D) Cohort of mice (saline, n = 6; nsens, n = 7; sens, n = 7) that was designed for DARPP-32 measures after SKF administration. * indicates significantly higher activity levels than those presented by the saline and nsens groups during the same test (p<0.05) and when compared to their own levels in test 1 (p<0.05).