Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
Figure 1
Time course of changes in PDH activity and ATP levels in the skeletal muscles, heart, lungs, liver and brain of IAV-infected mice.
Mice were infected with IAV/PR/8/34(H1N1) at 120 pfu intranasally and the levels of PDH activity (A) and ATP (B) in the skeletal muscles, heart, lungs, liver and brain were analyzed at days 0 (d0), 3 (d3) and 7 (d7) post-infection. PDH activity levels after IAV infection relative to the values at day 0. Data are mean ± SD of 5 mice per group. #P<0.05, ##P<0.01 vs. day 0, by one-way analysis of variance (ANOVA) with Tukey post hoc test.