Mycobacterium tuberculosis Multidrug Resistant Strain M Induces an Altered Activation of Cytotoxic CD8+ T Cells
Figure 5
M strain induces a deficient CD4+ T cell activation with low IL-2 expression.
PBMC from 11 PPD+ N (A, C and E) and 7 PPDNEG N (B, D and F) were cultured for 72 h alone or with Mtb strains H37Rv, M or 410 and then tested for surface expression of CD69 (A and B) and CD25 (C and D) and intracellular expression of IL-2 (E and F). Results are expressed as % of positive cells in the CD3+CD4+ lymphocyte gate. Data are shown as median and 25–75 percentiles. Statistical differences: PBMC+Mtb strains vs. control PBMC * = p<0.05, between strains: § = p<0.05.