Comparison of Airway Responses in Sheep of Different Age in Precision-Cut Lung Slices (PCLS)
Figure 2
Concentration-response curves for common mediators of early allergic response in PCLS of adult (•) and newborn sheep (▪).
A) methacholine, B) serotonin, C) histamine, D) endothelin-1, E) leukotriene D4 (LTD4), and F) U46619. n = number of PCLS, whereby a total of 7 newborn and 5 adult sheep were examined. Data are shown as mean ± SEM. A shared concentration-response curve was plotted for adult and newborn sheep, if no difference was found in any parameter of the 4−parameter logistic equation.