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A Toolbox for Tuberculosis (TB) Diagnosis: An Indian Multi-Centric Study (2006-2008); Evaluation of Serological Assays Based on PGL-Tb1 and ESAT-6/CFP10 Antigens for TB Diagnosis

Figure 6

Impact of mycobacterial load and antibody responses stratified by HIV status.

Relationship between individual time to positivity (TTP in days) of a liquid culture and individual serological tests based on optical density values against PGL-Tb1 antigen (blue spot) or ESAT-6/CFP10 (red spot) antigen in (A) the whole group of 270 HIV-uninfected and 293 HIV-unknown patients and in (B) the group of 68 HIV-infected patients with active pulmonary TB. The continuous lines represent the linear regression curve for anti-PGL-Tb1 antibody or for anti-ESAT-6/CFP10 antibody tested individuals; the hatched lines represent the 95% confidence intervals. Footnotes: HIV: Human Immunodeficiency Virus; OD: optical density; TTP: time to positivity.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0096367.g006