Ventilation-Induced Increases in EGFR Ligand mRNA Are Not Altered by Intra-Amniotic LPS or Ureaplasma in Preterm Lambs
Figure 2
In situ localization of EREG and AREG with LPS exposure and mechanical ventilation in lung.
(A–C) EREG mRNA was not found in (A) unventilated controls or (B) IA LPS exposed lungs, but dramatically increased in peripheral lungs of lambs receiving (C) mechanical ventilation. EREG mRNA is localized to dome-shaped cells in peripheral lung (C, Insert). (D–F) AREG mRNA is found scattered in the peripheral lung of (D) Unventilated controls with a mild increase with (E) IA LPS exposure. (F) Mechanical ventilation increases the mRNA signal in similar cells to EREG. Scale bar = 50 µm