Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide
Figure 7
Myeloid-specific deletion of Rictor does not affect metabolic homeostasis in mice fed a low or a high-fat diet.
(A–D) Body and tissue weight of LysM-RictorWT or LysM-RictorKO mice fed a (A and C) low or (B a D) high fat diet for 21 and 23 weeks respectively. (E) Blood parameters of LysM-RictorWT or LysM-RictorKO mice fed either a low or a high fat diet. Mice were fasted for 6 hours before blood collection. Ŧ denotes a significant difference between low fat fed and high fat fed mice (p<0.05). The p value for the genotype effect is indicated on the right side of the table. (F–G) GTT and ITT of LysM-RictorWT or LysM-RictorKO mice fed with (F) low or (G) high fat diet. For the panels A to G, n = 6–13 mice per group. (H–I) Gene expression in (H) WAT and (I) liver of LysM-RictorWT or LysM-RictorKO mice fed a low or a high fat diet. mRNA expression was measured by qRT-PCR and normalized to 36B4 mRNA levels. Data are expressed as the mean ± SEM for n = 6–10 per condition. Ŧ denotes a significant difference between low fat fed and high fat fed mice (p<0.05). * denotes a significant difference between LysM-RictorWT or LysM-RictorKO mice (p<0.05).