Efficacy of IFN-λ1 to Protect Human Airway Epithelial Cells against Human Rhinovirus 1B Infection
Figure 1
IFN-induced antiviral state protects against HRV1B infection in A549.
A549 were treated with IFNs for 18(n = 6). Fold-changes were calculated with the 2−ΔΔCt method (A). A549 were first treated with IFNs for 18 h. Next, according to the continuous and pre-treatment approaches, cells were infected with HRV1B and incubated for another 24 h (n = 6). After that, cells were collected for further analyses. Viral copies were determined by qPCR and fold-changes were calculated with the 2−ΔΔCt method (B). *, p<0.05 Control vs IFNs, HRV1B vs IFNs+HRV1B. #p<0.05 IFN-λ1 vs IFN-β.