Inhibition of Paracoccidioides lutzii Pb01 Isocitrate Lyase by the Natural Compound Argentilactone and Its Semi-Synthetic Derivatives
Figure 4
Effect of argentilactone, reduced argentilactone, epoxy argentilactone, and diol argentilactone on P. lutzii Pb01 differentiation from mycelium to yeast.
The mycelium was incubated for 10 days at 36°C on MMcM agar containing glucose or acetate and supplemented with different concentrations of argentilactone, reduced argentilactone, epoxy argentilactone, and diol argentilactone. Cell morphology was observed by optical microscopy in medium containing glucose (A) or acetate (B). The P. lutzii Pb01 yeast cells were counted using a Neubauer chamber in medium containing glucose (C) or acetate (D). *p<0,05.