Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus
Figure 6
Glycolysis, pentose phosphate pathway, and serine synthetic pathway.
(A) A metabolic map of glycolysis, the pentose phosphate pathway, and the serine synthetic pathway with gene expression is depicted in the same way as in Figure 4. Underlined: essential amino acid. Abbreviations: G1P, glucose-1-phosphate; G6P, glucose-6-phosphate; F6P, fructose 6-phosphate; F1,6P, fructose 1,6-diphosphate; DHAP, dihydroxyacetone phosphate; GA3P, glyceraldehyde 3-phosphate; 1,3PG, 1,3-Bisphosphoglycerate; 3PG, 3-Phosphoglyceric acid; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; 6PG, 6-phosphogluconolactone; Ru5P, ribulose 5-phosphate; X5P, xylulose 5-phosphate; R5P, ribose 5-phosphate; S7P, sedoheptulose 7-phosphate; E4P, erythrose 4-phosphate; X5P, xylulose 5-phosphate; PRPP, phosphoribosyl pyrophosphate; IMP, inosine monophosphate; Ser, serine; Gly, glycine; Thr, threonine. Symbols (¶, *, N.D., n.a.) represent the same meaning as in Figure 4A. (B) Immunoblot analysis of the selected enzymes. The control was the same beta-actin as in Figure 4B.