The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages
Figure 4
IL-6 enhances expression of markers typical of human AAMs.
Stimulation of human AAMs (IL-4+IL-13, 10 ng/mL 48 h) concomitantly with IL-6 (10 ng/mL) enhanced mRNA expression of CCL18 (A) and CD206 (B), and protein expression of CD206 (C) (mean±SEM; n = 7; *p<0.05 compared to macrophages (MØ), ANOVA followed by Dunnetts test; immunoblot is representative of 3 experiments).