Estimated Secondary Structure Propensities within V1/V2 Region of HIV gp120 Are an Important Global Antibody Neutralization Sensitivity Determinant
Figure 1
Schematic secondary and tertiary structure organization of the V1/V2 domain in HIV gp120.
Disulfide bridges are shown in yellow. Beta-strands(shown as block arrows) are assigned according to the X-ray structure (PDB ID 3U4E). In this structure stem region is replaced by an unrelated scaffold, but the stem is independently observed to form anti-parallel strands in multiple gp120 X-ray structures (e.g. PDB ID 2B4C). Dashed line indicates polypeptide chain segment unresolved in the available X-rays although N-terminal part of it has well-conserved sequence, including the integrin binding motif.