Interaction of 6 Mercaptopurine with Calf Thymus DNA – Deciphering the Binding Mode and Photoinduced DNA Damage
Figure 11
6MP induced damage to plasmid DNA in presence of light.
Agarose gel electrophoresis pattern of ethidium bromide stained pBR322 DNA after the treatment with 6MP in presence of white light. Lane ‘A’ depicts the ‘Control’ which contain only plasmid DNA. The concentrations of 6MP in lanes ‘B–F’ was 100, 200, 300, 400 and 500 μM respectively. Arrows indicating OC and SC on the right represent the open circular and supercoiled forms of plasmid DNA.