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Histaminergic Modulation of Cholinergic Release from the Nucleus Basalis Magnocellularis into Insular Cortex during Taste Aversive Memory Formation

Figure 2

Summary of microdialysis ACh sampling protocol in CTA behavioral paradigm.

Microdialysis samples were collected every 15-moving rats. A) During CTA acquisition, RAHM, pyrilamine, or saline was injected at the beginning of sample 5 (dark arrow), 30 min before saccharin consumption (gray bar), and LiCl was injected i.p. at the beginning of sample 11 (white arrow), 45 min after the saccharin consumption period had ended. B) During the CTA memory trial, ACh levels were measured in the absence of any injections.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0091120.g002