Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
Figure 2
eNOS phosphorylation in platelets from HD patients and healthy controls.
(A) Representative immunoblotting of eNOS phosphorylation at serine residue 1177 in platelets and densitometric analysis for p-eNOS(1177) and eNOS (left) and for eNOS and β-actin (right). (B) Bar graph showing endothelial NOS activity in platelets from early (I-II) and late (III-IV) stage HD patients and healthy controls. Young Ctrl n = 5; Old Ctrl n = 4; Early stage n = 9; Late stage n = 9. Data are shown as mean ± SD. *, p <0.05. (One-way ANOVA followed by Tukey post test). F = 8.766; df = 26.