Estimating Dose Painting Effects in Radiotherapy: A Mathematical Model
Figure 4
Simulated growth of a heterogeneous tumor with the low migration rate.
Depicted in dark and light green (respectively, dark and light red) are proliferating and quiescent CCs (respectively, proliferating and quiescent CSCs). Dead cells are represented in black. (A) An initial stage where about 105 cells, distributed into tumor cell phenotypes CC (85%) and CSC (15%), are present. (B) Tumor stage when radiation therapy is started (about 106 cells in total). In the middle image, the location of the inner region where 100% of CSCs are concentrated is shown for the case when and CSC cycle duration equal to 96 h. A 3D transversal cut is performed in the middle of solid figures (A) and (B) (left), so that its interior could be seen (middle and right) respectively. (C) Representation of the transversal cut showed in (B) for a slice of two cell diameters. Notice the little space existing between cells.