Anti-Tumor Effects of Novel 5-O-Acyl Plumbagins Based on the Inhibition of Mammalian DNA Replicative Polymerase Activity
Figure 7
Effect of C18:1-acyl plumbagin (2f) on the thermal transition of dsDNA.
Control (open-square), C18:1-acyl plumbagin (2f) (100 µM, closed-circle), and EtBr (15 µM, open-diamond) were incubated with 6 µg/mL of calf thymus dsDNA in 0.1 M Na-phosphate buffer (pH 7.0). Data are shown as the mean ± SD (n = 3). ** P<0.01 and * P<0.05 vs. controls.