Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin
Figure 5
In vivo effect of PPI on CisPt uptake.
A: Effect of PPI (25 mg/kg) on CisPt uptake by human tumour in SCID mice model. CTR: SCID mice treated with CisPt (0,1 mg/mouse), CTR+PPI: SCID mice pretreated with PPI and then with CisPt. p<0.05. B: Effect of PPI in SCID mice plasma on exosomes tumour release analysed by Exo Test. p<0.05. C: Effect of PPI on CisPt content in exosomes circulating in SCID mice. CTR: plasma exosomes of SCID mice treated with CisPt, CTR+PPI: plasma exosomes of SCID mice pretreated with PPI and then with CisPt. p<0.05. Representative of three independent experiments are reported.