Lithium Promotes Neuronal Repair and Ameliorates Depression-Like Behavior following Trimethyltin-Induced Neuronal Loss in the Dentate Gyrus
Figure 1
In “Schedule 1, 2, and 3,” animals were given TMT (2.9 mg/kg, i.p.), and then received 2 consecutive injections of BrdU (50 mg/kg, i.p.) with a 12-h interval between them on day 2 post-TMT treatment for labeling mitotic cells in the dentate gyrus. To examine the effect of acute treatment with lithium carbonate on the proliferation of neural progenitor cells at the initial time window following neuronal loss in the dentate gyrus of the impaired animals, we carried out experiments under the conditions of “Schedule 1 or 2.” To examine the effect of chronic treatment with lithium carbonate on survival and differentiation of the newly-generated cells in the dentate gyrus of the impaired animals, we carried out experiments under the conditions of “Schedule 3.”