Resveratrol Inhibits Cisplatin-Induced Epithelial-to-Mesenchymal Transition in Ovarian Cancer Cell Lines
Figure 9
Involvement of Resveratrol in the inhibition of Cisplatin-induced EMT.
Treatment of ovarian cancer cell lines with Cisplatin results in the activation of the Erk pathway and subsequent induction of Snail expression and induction of EMT. By contrast, Resveratrol prevents Cisplatin-mediated EMT induction by antagonizing the activation of the Erk pathway, thus preventing Snail levels increase and EMT induction. Furthermore, Resveratrol could also prevent Cisplatin-induced EMT through induction of a senescence program that would block the progression of other cellular differentiation programs like EMT.