Effect of Proton Pump Inhibitors on In Vitro Activity of Tigecycline against Several Common Clinical Pathogens
Figure 1
Time–kill curves showing effects of proton pump inhibitors (PPIs) on the activity of tigecycline.
MICT, MIC for tigecycline alone; MICL5 and MICL50, MIC for tigecycline in combination with 5 mg/L and 50 mg/L lansoprazole; MICA5 and MICA50, MIC for tigecycline in combination with 5 mg/L and 50 mg/L omeprazole; MICP5 and MICP50, MIC for tigecycline in combination with 5 mg/L and 50 mg/L pantoprazole. •, Control; ▴, 50 mg/L lansoprazole; ▾, 50 mg/L omeprazole; ▪, 50 mg/L pantoprazole; Δ, 5 mg/L lansoprazole; ▽, 5 mg/L omeprazole; □, 5 mg/L pantoprazole; ○, tigecycline alone. The in vitro time-kill experiments were duplicated; mean values are plotted. In all duplicate experiments, similar time-kill results were obtained.