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Longer Telomeres Are Associated with Cancer Risk in MMR-Proficient Hereditary Non-Polyposis Colorectal Cancer

Figure 1

Age-adjusted RTL in subjects belonging to fCRC-X and LS families.

The different groups correspond to: cancer-affected fCRC-X cases (median age-adjusted RTL: 0.017); cancer-free individuals from fCRC-X families (median: −0.215); cancer-affected MMR gene mutation carriers (median: −0.131); cancer-free MMR gene mutation carriers (median: −0.079); and cancer-free controls (median: −0.092). Differences in age-adjusted RTL were analyzed using the Wilcoxon rank sum test (Mann-Whitney U). The boxes represent the interquartile range of distributions (25th and 75th percentiles); the horizontal lines within the boxes, the medians; and the vertical lines, the 5th and 95th percentiles. Data from LS families and controls were published previously [16].

Figure 1

doi: https://doi.org/10.1371/journal.pone.0086063.g001