Hindlimb Suspension and SPE-Like Radiation Impairs Clearance of Bacterial Infections
Figure 5
Gamma irradiated mice treated with hindlimb suspension fail to control a challenge with Pseudomonas aeruginosa.
Groups of 10 C3H/HeN male (A) and female (B), Balb/c female (C) and ICR female (D) mice were gamma irradiated (2 Gy) and/or placed in hindlimb suspension. Five days later, mice were exposed to Pseudomonas aeruginosa by intraperitoneal injection and followed for 5 days. Morbidity scores (Table 1) were calculated daily and animals were considered morbid if their score increased by 3 points or remained elevated 2 points for 24 hrs. C = control, S = hindlimb suspended, R = irradiated, and R+S = irradiated and suspended. Statistical significance was measured by log rank analysis of Kaplan-Meier curves and expressed in the table as column versus rows.