The BDNF/TrkB Signaling Pathway Is Involved in Heat Hyperalgesia Mediated by Cdk5 in Rats
Figure 1
Heat hyperalgesia induced by CFA peripheral injection was significantly inhibited by intrathecal administration of roscovitine, K252a and TrkB-IgG.
PWL to thermal stimuli significantly decreased following intraplantar injection of CFA,**P<0.01, (n = 6/group) (A). PWL to thermal stimuli significantly increased following intrathecal injection of roscovitine 0.5 h prior to CFA injection compared to the PWL of the control group. **P<0.01, (n = 6 per group) (B). PWL to thermal stimuli significantly increased following intrathecal injection of K252a 0.5 h prior to CFA injection compared to the PWL of the control group. **P<0.01, (n = 6, per group) (C). PWL to thermal stimuli significantly increased following intrathecal injection of TrkB-IgG 0.5 h prior to CFA injection compared to the PWL of the control group, **P<0.01, (n = 6, per group) (D).