Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
Figure 6
Model of Resveratrol Signaling in HuVSMC Differentiation.
Resveratrol stimulates multiple second messengers that lead to AKT activation and the induction of differentiation. Low dose resveratrol stimulates SirT1, which activates AKT to induce differentiation. High dose resveratrol stimulates AMPK, which inhibits the mTORC1 pathway relieving the S6K1 inhibition on IRS-1, allowing activation of AKT and the induction of differentiation. Ultimately, resveratrol induces a multi-signaling cascade that results in robust vascular smooth muscle differentiation.