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Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents

Figure 10

Micrographs of samples from patients with hereditary hemochromatosis with added sodium selenite; A) Whole blood with added 10 mM sodium selenite (H63D/wild type); B) Whole blood, with added thrombin and 10 mM sodium selenite (H63D/wild type); C) Platelet rich plasma smear, with added thrombin and 10 mM sodium selenite (H63D/wild type); D) Whole blood with added 0.5 mM sodium selenite (H63D/wild type); E) Whole blood, with added thrombin and 0.5 mM sodium selenite (H63D/wild type); F) Platelet rich plasma smear, with added thrombin and 0.5 mM sodium selenite (H63D/wild type); G) Light microscopy of whole blood with 0.5 mM sodium selenite (C282Y/wild type).

All SEM micrographs scales = 1 µm; light microscopy micrograph scale = 10 µm.

Figure 10

doi: https://doi.org/10.1371/journal.pone.0085271.g010