Loss of Hippocampal Neurons after Kainate Treatment Correlates with Behavioral Deficits
Figure 8
Correlations between hippocampal neuron numbers and spatial learning and memory indices.
The x-axes represent the total numbers of neurons in the dentate hilus (A, B), and hippocampal CA3 (C, D) and CA1 (E, F) pyramidal fields in control and kainate-treated rats. The y-axes represent the percentages of savings during water maze training, i.e. the differences, in %, between the mean distances swum by rats on the first four trials and on the last four trials (A, C, E), and the percentages of time spent by rats in the training quadrant of the water maze during the probe trial (B, D, F). Data obtained from 6 animals randomly selected from each group (final n = 18) were used in the correlational analyses. Correlation coefficients are shown at the bottom of each plot and dashed lines represent 95% confidence intervals.