Improved Mitochondrial Function Underlies the Protective Effect of Pirfenidone against Tubulointerstitial Fibrosis in 5/6 Nephrectomized Rats
Figure 8
Effect of pirfenidone on cytochrome C, prohibitin and cleaved caspase-3/9 in HK2 cells.
(A) Western blotting analysis for cyto C and prohibitin; Quantification of cyto C and prohibitin. (B) Western blotting analysis for cleaved caspase 3 and cleaved caspase 9; Quantification of cleaved caspase 3/9. PFD, pirfenidone; Values are represented as the means±SEM of three replicates from three different experiments. * P<0.05, rotenone incubation vs. control; # P<0.05, PFD+rotenone incubation vs. rotenone incubation alone.