Genome-Wide and Differential Proteomic Analysis of Hepatitis B Virus and Aflatoxin B1 Related Hepatocellular Carcinoma in Guangxi, China
Figure 1
Whole-genome profiles and frequency plots of chromosomal alterations in HCC patients (z-scoring:2.5).
(A) The genomic alterations in tumor samples from each HCC patient (n = 32) are illustrated in individual vertical lanes. A total of 573 gene copy number alterations were mapped and ordered by chromosomal position from 1pter to Yqter using the workbench Lite Edition 6.5.0.18. Tumor versus the reference intensity ratios (in log2 ratio) for individual tumor samples are plotted in different color scales reflecting the extent of increases (red) or decreases (green) in copy number. The detail chromosomal alterations were shown in 1B (chromosome 1 to chromosome 12) and in 1C (chromosome 13 to chromosome 22, X chromosome and Y chromosome, respectively). Nine chromosomes showed increased chromosomal DNA (1q, 5p, 6p,7q, 8q, 17q, 20p, 20q and X) and 16 chromosomes had deceased chromosomal DNA (1p, 4q, 8p, 9p, 10q,13q, 14q, 16p, 16q ,17p ,18q, 19p ,19q, 21q, 22q and Y) that were repeatedly observed in > 20% of tumor samples.