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Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function

Figure 5

Orai1 expressing cells are abundant in synovial tissue from patients with rheumatoid arthritis.

Sections of synovial tissue from patients with rheumatoid arthritis or healthy controls were stained for Orai1 by immunohistochemistry with rabbit anti-Orai1 (Sigma), and the number of Orai1-positive immune cells was evaluated by assigning each stained tissue section a semi-quantitative score ranging from 0–4. A) Orai1 immunohistochemistry of rheumatoid arthritis synovial tissue. B) Magnification of A. C) Orai1 immunohistochemistry of normal synovial tissue. D) Histogram showing mean semi-quantitative scores of the number of Orai1-positive cells in synovial tissue from rheumatoid arthritis patients (RA) (n = 24) or normal synovial tissue (n = 11). Error bars, +/− SEM. Scale bars, 100 µm.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0082944.g005