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Predicting the Activity Coefficients of Free-Solvent for Concentrated Globular Protein Solutions Using Independently Determined Physical Parameters

Figure 1

Activity Coefficient of Free-Solvent Using Literature Values of the Physical Parameters vs. Concentration for BSA in 0.15 M NaCl, pH 4.5.

The calculated activity coefficients of BSA in 0.15(closed circles) are shown. The predicted activity coefficients (Eqn. 12) are plotted using the physical parameters available in literature for BSA in 0.15 M NaCl, pH 4.5 ( mol NaCl/mol BSA [6]): g H2O/g BSA (solid curve) and g H2O/g BSA (dotted curve).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0081933.g001