Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction
Figure 1
Lack of SGK1 correlated with reduced cardiomyocyte size.
(A) Cross sectional area in heart sections from WT and SGK1-/- mice. Area was measured in ≥10 distinct microscope field for each slide. Four hearts were analysed for each slide in both WT and SGK1-/- mice. Scale bar represents 50 µm. (B) Confocal images of isolated adult cardiomyocytes form WT and SGK1-/- mice The data represent the average of three independent experiments and are reported as Mean ± SE. Cell volume was measured using a custom-written macro in ImageJ. Scale bars represent 5µm. Statistical analysis has been performed as described in Materials and Methods using Student t-test; *** indicates p<0.001.