Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor
Figure 2
The effects of Doxorubicin (Dox), Mdivi-1 and the co-administration of Dox + Mdivi-1 on the haemodynamics of the heart.
The hearts underwent 20 minutes of stabilization followed by 120 minutes perfusion in the presence absence of drugs (alone and in combination).The effects of drug treatment on left ventricular developed pressure, b) heart rate and c) coronary flow as a percentage of the mean stabilization period. *p<0.05 vs. time matched control, **<0.01 vs. time matched control, #p<0.05 vs. time matched doxorubicin. n= 6-8.