Bortezomib Resistance Can Be Reversed by Induced Expression of Plasma Cell Maturation Markers in a Mouse In Vitro Model of Multiple Myeloma
Figure 5
LPS re-sensitizes Bz-resistant cells to bortezomib treatment.
72 hour LPS-treated or untreated BzS, BzR, or I-BzR lines were ficolled and re-plated in the presence or absence of 60 nM Bz for 48 hours. The percentage of live cells determined by CellTiter-Glo® values normalized to untreated controls (i.e. In the absence of Bz, LPS-treated were normalized to non-LPS-treated cells, and following LPS treatment, Bz-treated were normalized to non-Bz-treated cells) are shown. Error bars represent three independent CellTiter-Glo® readings. Significance was determined using a one-tailed Student’s t-test (***p<0.001; ****p<1×10−4; *****p<1×10−5).