Clinical, Molecular and Genetic Validation of a Murine Orthotopic Xenograft Model of Pancreatic Adenocarcinoma Using Fresh Human Specimens
Figure 3
Pathological comparisons of human and mouse tumors.
Hematoxylin and eosin (H&E) staining (100×) of human (F0), early (F1), and late (F7, F9) passage mouse tumors are shown (A), demonstrating preserved histologic architecture and stroma. H&E staining (200×) of a surgically implanted human tumor in the mouse pancreas (B); large arrowheads demonstrate normal pancreatic lobules, stars show interlobular fibrosis/chronic pancreatitis near the invasive tumor front, and smaller arrows demonstrate invading cancer cells.