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Neuroglobin Over Expressing Mice: Expression Pattern and Effect on Brain Ischemic Infarct Size

Figure 4

Ngb-IR in cortical areas.

In the piriform cortex Ngb-IR was only seen in few cells of WT mice (A-B). Conversely, intense Ngb-IR was seen in cell bodies and processes throughout the piriform cortex of Tg mice (C-D). In WT mice Ngb-IR was confined to 2–3 cell layers of the S1 (E-F) whereas in Tg mice Ngb-IR was seen scatter throughout all cortical layers (G-H). Black arrow exemplifies an Ngb over expressing cell body and black arrowhead over expressing processes. Abbreviations: Caudate putamen (CPu); Cingulate cortex, area 2 (Cg2); Corpus callosum (cc); Dysgranular insular cortex (DI); Piriform cortex (Pir); Primary somatosensory cortex (S1); Ventral hippocampal commissure (vhc). Scale bar 100 µm.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0076565.g004