Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism
Figure 4
Extracellular histones cause consumptive coagulopathy.
Plasma fibrinogen (A), APTT (B), and PT (C) of mice 10 minutes after injection with vehicle or histones (20-80 µg/g, n = 4-10). ** P < 0.01 compared with the vehicle group.