Mechanical Ventilation Enhances HMGB1 Expression in an LPS-Induced Lung Injury Model
Figure 4
Effect of HMGB1 blocking antibody on ventilator-induced lung injury in rats.
Animals received anti-HMGB1 blocking antibody intratracheally before challenged by LPS and MV. BALF concentrations of total protein (A) and IgM (B), neutrophils (C), lung MPO activity (D), lung wet/dry weight ratio (E), IL-1β (F) and MIP-2 (G) concentrations, and histopathology (H, I) were measured. H: MV+LPS; I: MV+LPS+ HMGB1 antibody. Data are expressed as mean±SD. *, p<0.05 vs IgY group.