Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
Figure 1
Preventive administration of rapamycin permits to decrease severity of EAM.
A: strength (time to fall) improvement in rapamycin-treated mice. B: gastrocnemius, quadriceps, and triceps muscle inflammatory infiltrates evaluated by histological grading after hematoxylin-eosin staining as illustrated in C. C: the first two upper images represent a gastrocnemius section of an EAM mouse untreated with a histological score of 4 (HE, ×20). The middle picture also shows an invaded/tunnelized fiber (arrow, HE, ×40). The third image panel represents a gastrocnemius section of a EAM mouse treated with 3 mg/kg/day of rapamycin, displaying a histological score of 1 (HE, ×20). D: correlation between muscle strength (time to fall) and histological grade of inflammation.