Anti-Wrinkle and Anti-Inflammatory Effects of Active Garlic Components and the Inhibition of MMPs via NF-κB Signaling
Figure 9
Effects of the three compounds on intracellular ROS/ONOO¯ in UVB-irradiated hairless mice.
(A) (B) ROS and ONOO¯ generations by UVB in hairless mouse skins were decreased concentration-dependently by pretreating animals with each of the three compounds. Results are expressed as means±SEs of three determinations. Significance was determined using one-factor ANOVA: # # # p < 0.001, # # p < 0.01 vs. control; *p < 0.05, **p < 0.01 and ***p < 0.001 vs. UVB-irradiated group; CA, caffeic acid; COX-2, cyclooxygenase-2; iNOS, inducible nitric oxide synthase; MMP1, matrix metalloproteinase1; MMP3, metalloproteinase3; MMP9, metalloproteinase9; MMP13, matrix metalloproteinase13; ONOO¯, peroxynitrite; ROS, reactive oxygen species ; UVB, ultraviolet B.