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CCDC65 Mutation Causes Primary Ciliary Dyskinesia with Normal Ultrastructure and Hyperkinetic Cilia

Figure 3

CCDC65 localization in ciliated airway epithelial cells.

(A) Schematic of a ciliary axoneme cross section, with the N-DRC enlarged (adapted from [30]). (B) Photomicrographs of CCDC65 immunofluorescent staining in nasal epithelial cells revealing cytoplasmic and axonemal localization of the protein in normal cells compared to decreased expression in epithelial cells collected from the PCD subject (CCDC65, red; acetylated α-tubulin, green; DAP, blue), Scale bar = 10 µm.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0072299.g003